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The pregnane x receptor

Webb18 apr. 2016 · The nuclear xenobiotic pregnane X receptor (PXR) is well established as a transcriptional regulator of phase I and phase II drug-metabolizing enzymes and drug … WebbThe nuclear pregnane X receptor (PXR; NR1I2) is an important component of the body's adaptive defense mechanism against toxic substances including foreign chemicals …

Pregnane X Receptor - an overview ScienceDirect Topics

WebbPregnane X Receptor (PXR), a member of the nuclear receptor (NR) superfamily, discovered in 1998 , represents a modular protein sharing common regions, a highly … Webb10 mars 2024 · Cheng J, Krausz KW, Tanaka N, Gonzalez FJ (2012a) Chronic exposure to rifaximin causes hepatic steatosis in pregnane X receptor-humanized mice. Toxicol Sci … domino\\u0027s bristol https://aweb2see.com

Pregnane X Receptor - YouTube

WebbPXR is remarkably divergent between species, with the rabbit, rat, and human receptors sharing only approximately 80% amino acid identity in their ligand-binding domains. … Webb29 sep. 2014 · Pregnane X receptor (PXR) is an important member of the nuclear receptor superfamily that copes with various endobiotic and xenobiotic stimuli, such as carcinogens by regulating an array of environmental response genes. Low PXR expression has been shown to promote tumor initiation and metastasis. The aim of the current study was to … WebbThe pregnane X receptor (PXR) regulates expression of proteins responsible for all three phases required for the detoxification mechanism, which include CYP450 enzymes, … domino\u0027s bribie island menu

A Role for the Pregnane X Receptor in High-Density Lipoprotein ...

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The pregnane x receptor

Identification of new human pregnane X receptor ligands among ...

Webb13 mars 2024 · Nuclear factor erythroid 2-related factor 2 (Nrf2) and pregnane X receptor (PXR) are important transcriptional factors that regulate the expression of anti-genotoxic phase II detoxification enzymes and phase III transporters [ 18, 19, 21, 22, 23 ]. プレグナンX受容体（プレグナンXじゅようたい、英: pregnane X receptor、略称: PXR）は、ヒトではNR1I2遺伝子によってコードされるタンパク質である 。SXR（steroid and xenobiotic sensing nuclear receptor）、NR1I2（nuclear receptor subfamily 1, group I, member 2）の名称でも知られる。

The pregnane x receptor

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Webb15 juli 2008 · Background: The pregnane X receptor (PXR; NR1I2), a member of the nuclear receptor superfamily, regulates the expression of metabolic enzymes and transporters … WebbThe pregnane X receptor (PXR) is a member of the nuclear receptor family of ligand-regulated transcription factors. Like many former orphan nuclear receptors, it contains …

WebbRecent studies have revealed that pregnane X receptor (PXR) can function as a master regulator to control the expression of phase I and phase II drug-metabolizing enzymes, … Webb2006 Orphan nuclear receptor pregnane X receptor sen-sitizes oxidative stress responses in transgenic mice and cancerous cells. Mol Endocrinol 20:279–290 24. Curnow KM, Tusie-Luna MT, Pascoe L, Natarajan R, Gu JL, Nadler JL, White PC 1991 The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex. Mol …

WebbThe pregnane X receptor (PXR) is a promiscuous nuclear receptor that has evolved to protect the body from toxic chemicals. PXR is activated by a structurally diverse … WebbEl receptor X de pregnano (PXR), también conocido como NR1I2 (de sus siglas en inglés "nuclear receptor subfamily 1, group I, ... MeSH: pregnane+X+receptor (en inglés) Datos: …

Webb18 mars 2009 · Pregnane X receptor (PXR) is an important component of the body's adaptive defense system responsible for the elimination of various toxic xenobiotics. …

Webb1 nov. 2006 · The pregnane X receptor (PXR) is a major chemical sensor known to activate the expression of CYP3A/Cyp3a in humans and rodents. The purpose of this study is to … qg tackle\\u0027sWebb29 okt. 2013 · Pregnane X receptor (PXR, NR1I2), a member of the nuclear receptor superfamily, is a crucial regulator of nutrient metabolism and metabolic detoxification … domino\u0027s brightonWebbThe pregnane X receptor (PXR) is a xenobiotic nuclear receptor that is also sensitive to bile acids as ligands.10,11 A study in this issue of Arteriosclerosis, Thrombosis, and Vascular Biology has examined the potential for PXR to regulate hepatic apoA-I and HDL formation in response to bileacids.12 Wild-typemice,miceinwhichthePXRgenehad qg smoke club