Phospholipase a2 receptor antibody panel
WebMar 8, 2024 · Phospholipases (PLs) are fundamental lipolytic enzymes for living organisms. They are classified in different families (A1, A2, B, C and D), distinguishable by the position where they induce lipid hydrolysis [1,2].The PLA2 family is involved in the cleavage of an sn-2 ester bond of the glycerophospholipid substrate, with the consequent generation of 1-acyl … WebApr 22, 2024 · The accuracy of the anti-phospholipase A2 receptor antibody in the diagnosis of idiopathic membranous nephropathy: A comparison of different cutoff values as measured by the ELISA method. Int. Urol.
Phospholipase a2 receptor antibody panel
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WebThe major antigen responsible for the autoantibody binding in IMN patients was identified to be the phospholipase A 2 receptor (PLA 2 R) [ 8 ], an integral transmembrane receptor that binds and removes the secreted phospholipase A 2 enzyme (sPLA 2) from circulation. WebAnti-phospholipase A2 receptor autoantibody (PLA2R-Ab) plays a critical role in the pathogenesis of primary membranous nephropathy (PMN), an autoimmune kidney disease characterized by immune deposits in the glomerular subepithelial spaces and proteinuria. However, the mechanism of how PLA2R-Abs interact with the conformational epitope(s) …
WebThe presence of antibodies against phospholipase A2 receptor (PLA2R-Abs) in serum at diagnosis is reported to be related to the rate of spontaneous remission in patients with idiopathic membranous nephropathy (IMN); however, there is still lack of enough samples to illustrate this problem. WebTest Usage. Primary membranous nephropathy is an autoimmune disease which demonstrates autoantibodies to the M-type phospholipase A2 receptor (PLA2R) in up to …
WebMay 24, 2024 · Anti-PLA2R antibodies are highly specific to primary MN, however anti-PLA2R antibodies have been identified in some secondary MN such as hepatitis B (HBV) … WebJun 1, 2024 · Primary membranous nephropathy is the most common cause of nephrotic syndrome in nondiabetic Caucasian adults. 1 Primary membranous nephropathy (PMN) is considered a renal-limited autoimmune disease with circulating autoantibodies against the phospholipase A2 receptor (aPLA2R1ab) present in 70% to 80% of patients.2,3 After 5 to …
WebMar 30, 2024 · The autoimmune nature of adult MN was first discovered upon the identification of antibodies to the phospholipase A2 receptor (PLA2R), located within …
WebOct 31, 2024 · Recently, great progress has been made in understanding the pathogenesis of membranous nephropathy (MN) with the discovery of autoantibodies (Abs) to M-type phospholipase A2 receptor (PLA2R) in serum and in immunocomplexes deposited in glomerulus in most adult patients with primary MN. Objective iowa lease pdfWebNRF2抗體Vimentin antibody產品介紹: This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury ... open book extracts stockWebThe enzyme phospholipase A2 (EC 3.1.1.4, PLA2, systematic name phosphatidylcholine 2-acylhydrolase) catalyse the cleavage of fatty acids in position 2 of phospholipids, … open book goldsmiths universityWebThe characterization of the phospholipase A2 receptor (PLA2R) as the major target antigen in primary MN and the detection of circulating autoantibodies in these patients is a major advance in understanding this disease. iowa lease terminationWebBackground. The pathogenesis of primary membranous nephropathy (MN) involves the antibodies against antigens on the cell surface of podocytes, with the majority of M-type … open book extracts ncWebThe anti-PLA2R ELISA (IgG) test kit is intended for the qualitative or semiquantitative determination of IgG class autoantibodies against phospholipase A2 receptor (PLA2R) in … open book extracts thcvWebCD44抗體Vimentin antibody產品介紹: The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). openbook freedom scientific