Klotho polymorphisms longevity

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August undefined, 2024

WebJul 1, 2024 · Klotho, a longevity factor, enhances cognition when genetically and broadly overexpressed in its full, wild-type form over the mouse lifespan. Whether acute klotho treatment can rapidly enhance cognitive and motor functions or induce resilience is a gap in our knowledge of its therapeutic potential. Here, we show that an α-klotho protein ... WebFeb 20, 2014 · Nowadays is clearly evident that genetic background constitutes integral part of successful ageing and longevity. Many studies on long lived people have been...

KLOTHO polymorphisms and age-related outcomes in …

WebMay 22, 2024 · Klotho polymorphisms have been previously associated with longevity (defined, depending on the study, as people over the age of 66, 75 or 93 years) in … WebThe main spot of Klotho activity is kidney and in the physiological state presumably the most important one. 6 This idea is warranted by the study made on mice with a kidney-specific ablation of Klotho which demonstrated the phenotype of global Klotho knockout mice. 21 The serum soluble Klotho was declined about 80% in those kidney-specific ... landline phones with good speakers

Longevity Gene Boosts Brainpower, Even in the Young

WebThis study correlated the VDR gene polymorphisms (FokI, ApaI, BsmiI, and TaqI) with frailty, computed by frailty index (FI), in 202 persons (127 women and 75 men, aged from 60 to 116 years), aiming to capture the involvement of vitamin D in the sex-frailty paradox. ... Klotho is a bona fide longevity gene that, if inactivated, generates a ... WebApr 16, 2014 · Indeed, many single-nucleotide polymorphisms (SNPs) associated with longevity were identified in genes encoding proteins that take part in this metabolic … WebApr 15, 2024 · Klotho is a transmembrane protein that is involved in promoting longevity in mammals. The KLOTHO (KL) gene, which is found in chromosome 13q12, has major and minor alleles . The minor allele is a haplotype of two single nucleotide polymorphisms (SNPs), with the IDs rs9536314 and rs9527025, which remain in perfect linkage … landline phone that blocks unwanted calls

Longevity Gene KLOTHO and Alzheimer Disease—A Better …

The Klotho gene G-395A polymorphism and metabolic

WebAug 30, 2016 · Klotho is the name of the Greek goddess who spins the web of time and regulates the span of life. In both humans and experimental animals, Klotho promotes longevity, while disturbances in Klotho ... WebThe Klotho KL-VS variant is associated with an increase in the incidence of dementia in older men, in a dose-dependent fashion (intermediate for heterozygosis and highest for … landline phone to ethernet adapterWebOct 13, 2024 · Reduced expression of the Klotho gene or α-Klotho protein level are associated with a shorter lifespan and risk of neurodegenerative diseases, as well as … landline phones with robocall blocking

"WebApr 16, 2024 · Its discovery in mice in 1997 was highly exciting because KLOTHO knockout mice had a short lifespan and showed a phenotype reminiscent of human aging. 1 In … " - Klotho polymorphisms longevity

Klotho polymorphisms longevity

KLOTHO polymorphisms and age-related outcomes in …

WebApr 16, 2024 · Its discovery in mice in 1997 was highly exciting because KLOTHO knockout mice had a short lifespan and showed a phenotype reminiscent of human aging. 1 In humans, a KLOTHO polymorphism called KL-VS is associated with extreme longevity. 2 Footnotes Go to Neurology.org/N for full disclosures.

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WebOct 28, 2013 · Klotho is a single protein associated with accelerated aging, and its overexpression is known to increase healthy lifespan by 30 percent (Cheikhi et al., 2024). Known to compress the period of... WebMar 1, 2024 · Klotho gene polymorphisms have been implicated in healthy aging, but inconsistences in findings from previous case-control studies have raised concerns regarding the associations between KLOTHO gene polymorphisms and susceptibility to aging-related diseases and longevity. Hence, this meta-analysis was performed. We …

WebJan 15, 2002 · To determine whether the KLOTHO gene is involved in human aging, we used a population-based association study employing two newly characterized flanking microsatellite markers. Marker 1 is ≈11 kb 3′ of the last exon, and Marker 2 is ≈66 kb 5′ of the first exon. We present evidence that the KLOTHO locus is associated with human … WebJul 1, 2024 · Longevity Gene KLOTHO and Alzheimer Disease—A Better Fate for Individuals Who Carry APOE ε4 Dementia and Cognitive Impairment JAMA Neurology JAMA …

WebJun 5, 2014 · This study investigated polymorphisms of a metabolism-related gene, Klotho, and an inflammatory gene, IL6, for association with the aging process in a healthy Han … WebApr 16, 2014 · Indeed, many single-nucleotide polymorphisms (SNPs) associated with longevity were identified in genes encoding proteins that take part in this metabolic …

WebAssociation Between a Functional Variant of the KLOTHO Gene and High-Density Lipoprotein Cholesterol, Blood Pressure, Stroke, and Longevity Dan E. Arking, Gil Atzmon, Albert Arking, Nir Barzilai, Harry C. Dietz Abstract—We previously identified a functional variant of KLOTHO, termed KL-VS, that is associated with human aging

WebAlzheimer's disease (AD) is the most common type of senile dementia.The antiaging gene Klotho is reported to decline in the brain of patients and animals with AD. However, the role of Klotho in the progression of AD remains elusive. The present study explored the effects and underlying mechanism of Klotho in a mouse model of AD. landline phones with simWebAug 27, 2024 · Klotho has been recognized as a gene involved in the aging process in mammals for over 30 years, where it regulates phosphate homeostasis and the activity of … landline phones with voice activated dialingWebphisms (SNPs) associated with longevity were identiﬁed in genes encoding proteins that take part in this metabolic pathway. Closely related to this pathway is the Klotho gene. landline phone that lights up when ringingWebFeb 15, 2016 · To investigate the possible association of the Klotho G-395A polymorphism and metabolic syndrome (MetS) among a population of Chinese nonagenarians and … helvex h3002WebMar 1, 2024 · Klotho polymorphisms have been previously associated with longevity (defined, depending on the study, as people over the age of 66, 75 or 93 years) in … landline phone that can block numbersWebApr 15, 2024 · Klotho is a transmembrane protein that is involved in promoting longevity in mammals. The KLOTHO (KL) gene, which is found in chromosome 13q12, has major and … landline phone systems small officesWebKlotho KL-VS variant in longevity was the PubMed data-base (from January, 2003, to September, 2013) limited to English language literature. The medical subject headings ... KLOTHO POLYMORPHISMS ... landline phone touch screen