Klf5 chip

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August undefined, 2024

WebOct 28, 2024 · Klf5 is an essential regulator of cell fate during early embryonic development, and it can also be used to generate pluripotent stem cells and to maintain their potency and self-renewal... WebOct 15, 2024 · Chromatin immunoprecipitation (ChIP) assays indicate that the Fgf4 locus is occupied by Klf5, suggesting direct regulation of Fgf4 by Klf5. In terms of the emergence of Nanog + pluripotent EPI cells, the phenotypes of Klf5 KO embryos can be reversed by either Fgfr or ERK inhibition.

ENCSR974OFJ – ENCODE

WebFeb 21, 2024 · Krüppel-like Factor 5 (KLF5) is a cell-intrinsic oncogene to promote tumorigenesis. However, the cell-extrinsic effects of KLF5 on suppressing the immune … WebHIF-1α活化对肾小管间质炎症和纤维化的影响及其机制探讨.pdf phenytoin and heart rate

Klf5 establishes bi-potential cell fate by dual regulation of ICM

WebKLF5 is a Krüppel-like transcription factor broadly involved in development and regeneration whose lineage specificity, if any, remains unclear. Here we report KLF5 specifically marks the epidermis, and its deletion leads to skin barrier dysfunction in vivo. WebKLF5 (Kruppel-like factor 5, IKLF, Basic transcription element-binding protein 2, BTEB2) is a zinc-finger transcription factor that plays a role in cell proliferation, differentiation, cell … http://genesdev.cshlp.org/content/36/13-14/822.long phenytoin and hyponatremia

The circROBO1/KLF5/FUS feedback loop regulates the liver …

Klf5 establishes bi-potential cell fate by dual regulation of ICM and …

WebOct 15, 2016 · Abstract. Krüppel-like factor 5 (Klf5) is a zinc-finger transcription factor that controls various biological processes, including cell proliferation and differentiation. We … WebDec 15, 2024 · KLF5 is selectively essential to multiple epithelial cancer types. A, Distribution of KLF5 CRISPR dependency score across cancer cell lines from the DepMap project. B, … phenytoin and haloperidol interactionWebKLF5 was bound primarily at promoters, intergenic regions, and within genes. To determine which of the genes that were differentially expressed on KLF5 depletion were direct targets, we intersected the Calu-3 ChIP-seq dataset with the DEGs identified by RNA-seq ( Fig. 2 B ). phenytoin and keppra taken together

"WebSep 7, 2024 · KLF5 is a member of the Kruppel-like factor, subfamily of zinc finger proteins that are involved in cancers. KLF5 functions as a transcription factor and regulates the … " - Klf5 chip

Klf5 chip

KLF5 Gene - GeneCards KLF5 Protein KLF5 Antibody

WebMar 21, 2024 · KLF5 (KLF Transcription Factor 5) is a Protein Coding gene. Diseases associated with KLF5 include Cardiomyopathy, Dilated, 1Ff and Sigmoid Disease.Among its related pathways are White fat cell differentiation and RNA Polymerase I Promoter Opening.Gene Ontology (GO) annotations related to this gene include DNA-binding … WebMar 10, 2024 · The mRNA and protein expressions of KLF5 and ASK1 were increased in NP tissues of IDD mice when compared to control mice (Fig. 2 a, b). In addition, chromatin immunoprecipitation (ChIP)-PCR experimental results showed that HDAC4 overexpression significantly enriched HDAC4 in the KLF5 promoter region (Fig. 2 c).

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WebKLF5 ChIP-seq on human GM12878 Nucleic acid type DNA Size range 450-650 Platform Illumina HiSeq 2000 Controls ENCSR398JTO Attribution Lab Michael Snyder, Stanford Award U54HG006996 (Michael Snyder, Stanford) Project ENCODE External resources GEO:GSE127670 References PMID:31969180 PMCID:PMC7333332 PMCID:PMC6724667 … WebNov 9, 2024 · Klf5 is essential for bi-potential cell fate; a single Klf5 -overexpressing embryonic stem cell (ESC) generates terminally differentiated embryonic and extra …

WebJan 14, 2016 · In vitro, KLF5 was required for the expression of a subset of epithelial identity genes, such as keratins and mucins, for the maintenance of histone acetylation at a large fraction of enhancers selectively active in well-differentiated PDAC cells and, to a lesser extent, for the repression of genes associated with the mesenchymal program and with … WebOct 22, 2009 · The Krüppel-like factor 5 (KLF5) is a zinc-finger transcription factor promoting cell proliferation, cell-cycle progression and survival. A high expression level of KLF5 mRNA has been shown to be associated with shorter breast cancer patient survival. However, the mechanism of KLF5 action in breast …

WebOct 1, 2024 · TP63, SOX2, and KLF5 Establish a Core Regulatory Circuitry That Controls Epigenetic and Transcription Patterns in Esophageal Squamous Cell Carcinoma Cell Lines - ScienceDirect Gastroenterology Volume 159, Issue 4, October 2024, Pages 1311-1327.e19 Original Research Full Report: Basic and Translational—Alimentary Tract WebSep 7, 2024 · Overall, five samples of KLF5 ChIP-Seq datasets were obtained, plus PCGs and lncRNAs with a KLF5 binding site in at least two samples were selected for the first step. Second, the differently expressed lncRNAs and PCGs were obtained from the intersection results of the RNA-Seq dataset (GSE50760) and Cancer RNA-Seq Nexus database. ...

WebFeb 10, 2008 · Interestingly, the ChIP-on-chip data revealed a weak signal of Klf2, Klf4 and Klf5 occupancies at the Fgf5 and Nes promoters. This binding was confirmed using ChIP–qPCR assays, and showed...

WebOct 7, 2024 · To determine direct gene targets of KLF5, we defined the cistrome of KLF5 using ChIP-seq in both Calu-3 and 16HBE14o- lung epithelial cells lines. Occupancy site concordance analysis revealed that KLF5 co-localized with the active histone modification H3K27ac and also with binding sites for CCAAT Enhancer Binding Protein Beta (C/EBPβ). phenytoin and hypernatremiaWebOverview. A cell-permeable phenylpropenoate compound that inhibits the proliferation of colon cancer cell lines exhibiting high levels of KLF5 (IC 50 = 1.6 µM in DLD-1 cells). … phenytoin and liver diseaseWebMar 17, 2024 · ChIP with the KLF5 antibody from R&D (#AF3758) was performed using the SimpleChIP® Enzymatic Chromatin IP Kit (Cell Signaling, #9003) following the manufacture’s instructions. Primers for these analyses are listed in Supplementary Table 3. The SYBR green (Takara, Mountain View, CA) method was used with the 7500 Fast Real … phenytoin and levetiracetam