Flotillin family protein

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August undefined, 2024

WebRecent work has provided new insights into the trafficking and targeting of flotillin and other PHB domain proteins. While the function of this large family of proteins remains unclear, … WebCadherin-1 or Epithelial cadherin (E-cadherin), (not to be confused with the APC/C activator protein CDH1) is a protein that in humans is encoded by the CDH1 gene. Mutations are correlated with gastric, breast, colorectal, thyroid, and ovarian cancers.CDH1 has also been designated as CD324 (cluster of differentiation 324). It is a tumor suppressor gene.

Flotillin-1 downregulates K+ current by directly coupling

WebSep 18, 2012 · The family of flotillin proteins consists of two homologous members, flotillin-1 and flotillin-2, also termed “reggies”, with flotillin-1 being identical to reggie-2 … WebOct 1, 2005 · The flotillin family is composed of two highly homologous proteins, flotillin 1 and flotillin 2, characterized by the presence of a prohibitin homology (PHB) domain, which is responsible for ... signs of effusive- constrictive pericarditis

IJMS Free Full-Text Mitogen-Activated Protein (MAP) Kinase ...

WebOct 4, 2005 · May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. Sequence similarities. Belongs to the band 7/mec-2 family. Flotillin subfamily. Cellular localization. Cell membrane. Membrane > caveola. Melanosome. Endosome. Membrane-associated … WebApr 13, 2024 · Patellins, a protein family that has PI-binding activity, have been identified in plant-derived EVs, providing a basis for this hypothesis that requires future investigation. FCW = fungal cell wall, FM = fungal membrane, FMT = fungal memtub, FLOT/REM = flotillin/remorin, LE = late endosome, PCW = plant cell wall, PATL = patellin, PS = … WebFlotillin is a family of lipid-membrane-associated proteins found in bacteria, archaea and eukaryotes. The family is found in association with pfam01145, another integral … therapeutic farm massachusetts

Flotillin-1 Antibody Cell Signaling Technology

FLOT1 - Wikipedia

WebThe formation of lateral microdomains is emerging as a central organizing principle in bacterial membranes. These microdomains are targets of antibiot… WebJul 11, 2005 · Text Box 1. Flotillin-2 discovery: Flotillin-2 was actually the first member of the flotillin family to be cloned. However, it was unwittingly discovered in a hybridoma … therapeutic feeding trayWebApr 1, 2009 · Flotillin-1 (FLOT1 or reggie-2) and flotillin-2 (FLOT2 or reggie-1) are ubiquitously expressed proteins in mammalian cells (Babuke and Tikkanen, 2007).They are approximately 50% identical in their amino acid sequence, and belong to a large family of proteins containing a stomatin-prohibitin-flotillin-HflK/C (SPFH) domain, a motif that is … signs of ehlers danlos weight

"WebMar 1, 2013 · We will not only review the well-known members of the family, such as kinase suppressor of Ras (KSR), but also put a special focus on the function of the recently identified or less studied scaffolders, such as fibroblast growth factor receptor substrate 2, flotillin-1 and mitogen-activated protein kinase organizer 1. " - Flotillin family protein

Flotillin family protein

High Expression of FLOT1 Is Associated with Progression and Poor …

WebJun 26, 2013 · Background The flotillin family member flotillin-1 (FLOT1) encodes a caveolae-associated, integral membrane protein that belongs to lipid raft family and involves in vesicular trafficking and signal transduction. However, the role of FLOT1 in development and progression of cancer remains largely unknown. The present study … WebApr 10, 2024 · Herpesvirus envelope glycoprotein B (gB) is one of the best-documented extracellular vesicle (EVs)-incorporated viral proteins. Regarding the sequence and structure conservation between gB homologs, we asked whether bovine herpesvirus-1 (BoHV-1) and pseudorabies virus (PRV)-encoded gB share the property of herpes simplex-1 (HSV-1) …

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WebTwo scaffold proteins, FLOTILLIN 4 (FLOT4) and the remorin protein SYMREM1, facilitate the formation of membrane nanodomains, reducing the mobility of the NF receptors, and this appears vital for appropriate rhizobial infection . While the symbiosis signalling pathway is important for infection, there is little evidence that this transduction ... WebMar 1, 2008 · The flotillin-2 protein induction was observed as early as 12 hours after TAp73β or TAp63γ overexpression. Even when Saos-2 cells were infected with Ad-p53 …

WebFeb 9, 2024 · The flotillin (FLOT)/reggie protein family is integral membrane element and contains two isoforms: flotillin-1 (reggie-2) and flotillin-2 ... Here, we demonstrate that … WebMar 21, 2024 · Flotillin-1 protein is upregulated in human endometrial cancer and localization shifts from epithelial to stromal with increasing tumor grade; ... ATP-binding cassette, sub-family A (ABC1), member 1 forms a complex with syntaxin 13 and flotillin-1, residing at the plasma membrane and in phagosomes;

WebOct 28, 2024 · Membrane surveillance and repair is of utmost importance to maintain cellular integrity and allow cellular life. Several systems detect cell envelope stress caused by antimicrobial compounds and abiotic stresses such as solvents, pH-changes and temperature in bacteria. Proteins containing an Stomatin, Prohibitin, Flotillin, and HflK/C … Webanalysis of the cDNA for this protein has provided new avenues by which to explore the structure and function of caveolae organelles. Interestingly, flotillin is a close homologue …

WebFlotillin 2 is a direct transcriptional target of the p53 family member genes in human cancer cells. The interaction of flotillin-2 with amyloid precursor protein (APP) promotes the clustering of APP at the cell surface. Coassembly of flotillin1 and flotillin2 into microdomains induces membrane curvature, the formation of plasma-membrane ...

WebAn important cell membrane protein is found to have a role in regulating ion transport in plant cells, which could help plants be more salt-tolerant. ... Flotillin proteins in the membranes of ... signs of edema in feetWebRecombinant protein within human Erlin-2 aa 50-200 (Lumenal). ... SPFH domain family, member 2; SPFH domain-containing protein 2; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2; UNQ2441 基因别名: BC036333; C87251; C8orf2; Erlin-2; ERLIN2; NET32; SPFH2; SPG18; UNQ2441/PRO5003/PRO9924 signs of elderly cat dyingWebOct 20, 2024 · For FLOT1-/FLOT2-positive early endosomes, we identify >300 putative cargo proteins and confirm eleven substrates for flotillin-dependent endocytosis, including the latrophilin family of adhesion ... therapeutic feedback testingWebSep 10, 2014 · The flotillin protein family consists of flotillin-1 and 2 (also called reggies) which homo- and hetero-oligomerize [2, 37]. Despite some other functions [ 4 , 32 ], flotillins have been linked to endocytosis and vesicular trafficking but also to signaling [ 6 , 8 , 14 , 15 , 24 , 33 , 36 , 38 ]. therapeutic fibletsWebThe flotillin family comprises flotillin 1 and flotillin 2 proteins, which are highly homologous (sharing 50% sequence identity). A clathrin independent pathway mediated by proteins called Flotillins, localized within lipid rafts … signs of elevated icpWebMar 26, 2024 · Flotillin-1 and flotillin-2 are ubiquitously expressed, membrane-associated proteins involved in multifarious cellular events from cell signaling, endocytosis, and … signs of egg bound henWebNov 28, 2024 · The flotillin family is composed of two highly homologous members: flotillin-1 (flot-1 or reggie-2) and flotillin-2 (flot-2 or reggie-1) 12. Both members of the family are ubiquitously expressed ... therapeutic food